Candidiasis Therapeutics – Pipeline Analysis 2019, Clinical Trials and Results, Patents, Designations, Collaborations, and Other Developments

Overview

Candidiasis is an infection caused by a common type of fungus or yeast called Candida albicans, which is normally found in the mouth, skin, vagina, stomach, and intestines. Generally, the immune system controls it in the body, however, overgrowth of the fungus due to weakened immune system because of illness, and consumption of medications that kill some other harmless bacteria in the body, giving the Candida albicans. more room to grow, which might lead to this disease.

Candida infection in mouth is also called thrush, which causes throat pain, pain when swallowing, change in taste, nausea, and loss of appetite. It can spread further down the throat to the stomach. Whereas, Candida infection in vagina results in itching, burning, redness, and soreness in the genital area and a thick white discharge. The diagnosis of the disease is difficult as patients show different signals and symptoms according to age, gender, host resistance, and exposure to environmental factors. However, certain tools such as questionnaire, comprehensive digestive stool analysis (CDSA), and laboratorial techniques such as biochemical assays are used to screen and determine the presence of yeast infections.

Candidiasis is usually treated using topical and systemic therapies. Topical treatments include miconazole (McNEIL-PPC Inc.), a cream containing miconazole nitrate; and systemic therapies include fluconazole (Pfizer Inc.), an orally-administered synthetic triazole antifungal agents.

A number of drug manufacturers are actively involved in the development of candidiasis therapeutics. For instance, Mycovia Pharmaceuticals Inc. is developing VT-1161, an orally-available inhibitor of fungal CYP51 for the treatment of recurrent vulvovaginal candidiasis. Mycovia completed phase IIb study of VT-1161 in December, which showed that VT-1161 was very well tolerated and had potent activity against a range of Candida species, including Candida glabrata, which has shown the resistance to other antifungal agents such as fluconazole.

Positive clinical trial results and adoption of collaboration strategies are enhancing candidiasis therapeutics pipeline. Moreover, the issuance of patents helps in achieving different milestones in the form of grants and designations from regulatory bodies and institutes, including the U.S. Food and Drug Administration (USFDA), the European Medicines Agency (EMA), and the National Institutes of Health (NIH), among others.

Pipeline Analysis

As of March 2019, the candidiasis therapeutics pipeline comprised 25+ drugs in different stages of development.

Epidemiology Analysis

The report provides epidemiology forecast of candidiasis for seven major markets, such as the U.S., Japan, and EU5 countries (the U.K., Germany, France, Italy, and Spain). It covers prevalent population and treated patient population for the period 2016–2028. According to an article published in The Lancet 2018, 75% of women develop vulvovaginal candidiasis (thrush or yeast infection) at least once in their lifetime.

Competitive Landscape

Some of the key players involved in the development of candidiasis therapeutics are Mycovia Pharmaceuticals Inc., Matinas BioPharma Inc., Sosei Group Corporation, Cidara Therapeutics Inc., Nosopharm, and SCYNEXIS Inc.

Report Insights

Some highlights of the report “Candidiasis Therapeutics – Pipeline Analysis 2019, Clinical Trials and Results, Patents, Designations, Collaborations, and Other Developments” have been mentioned below:

• Detailed pipeline analysis of therapeutic candidates that are being developed for the treatment of candidiasis, and estimates and analyses of emerging therapies and their progress status in different phases of development
• Comprehensive insights into pipeline products, with special focus on strategic developments of key players, information on drug licensing, designations, financing, and grants, technological advancements, patents, and upcoming conferences
• Competitive analysis and extensive information on monotherapies, combination therapies, targets and mechanisms of action, and drug origin with relevance to candidiasis
• Epidemiology forecast of candidiasis for seven major markets, including the U.S., Japan, and EU5 countries
• Analysis of marketed products for the treatment of candidiasis
• Detailed regulatory framework for drug approval in the U.S., Europe, and Japan
• Key winning strategies of the companies involved in the development of candidiasis therapeutics, followed by Pharma Proff’s views